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Menstruation during and after the Esmía - complete recovery of the cycle

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Esmia is a new generation drug for alternative treatment of uterine fibroids. In 2014 he was represented by a Hungarian company. Available in the form of tablets of 5 mg. For several years of use has helped many women avoid the removal of the uterus. The operation is limited only to the elimination of nodes. A unique tool with a striking effect. To date, analogues of the drug can be listed on the fingers of one hand. The therapeutic effect and the active ingredient most similar drug Dwell.

The active substance Esmii - ulispristal, affects progesterone receptors, reduces the amount of the hormone. Scientists have proven that a surplus of progesterone in a woman’s body causes an overgrowth of the endometrial layer. Leads to the formation of fibroids, uterine bleeding. The monthly cycle is broken. And how do the menses flow during the taking of the Esmea? After all, a constant obstacle in the development of an important sex hormone can not affect the menstruation.

The drug directly affects the formation of the endometrial layer. When treating uterine fibroids, tablets are taken for a long time. Every day in the dosage of 5 mg. During the menstrual cycle, uterine bleeding stops, discharge becomes scarce, then disappears altogether, and new ones do not come. All this is explained by hormonal changes in the female body. Violation of the natural activity of the reproductive system.

The drug affects the amount of hormones in a woman's body, due to a lack of progesterone, malfunction of the uterus occurs. The layer of the epidermis is formed weakly, with disturbances, cystic formations appear, which in turn, prevent the growth of the neoplasm. When it comes time to the next menstruation, there is simply no menstruation. There is nothing to reject from the walls of the uterus. The treatment of fibroids lasts about 3 months. By decision of the attending physician can be continued. In the first month, there is a decrease in bleeding, but there is a discharge in the form of a brown daub. In the period of expected monthly discharge, it increases slightly, but differs significantly from the usual. Scanty discharge continues to be present in the second month of taking the drug. On the third - the monthly no longer come at all. Intermediate secretions also disappear.

Restoring the cycle after the abolition of Esmea

After drug withdrawal, the monthly cycle is restored within 5 weeks. All transformations in the reproductive system that occur during the treatment of uterine fibroids are reversible. A woman's body is fully restored after therapy. And it does not require a long time. The next month should come regular monthly. And a month later, ovulation will resume. Daily administration of the drug does not allow the ovum to develop; it prevents the onset of ovulation.

That is how it should be. But in practice, the situation may be different. Menstruation may be absent for more than 3 months. This is due not so much to the drug as to the peculiarity of the body and the effectiveness of treatment. If the seal layer of the epidermis is present 3 months after discontinuation of the drug, it is necessary to conduct an additional examination.

Esmia affects myomatous cells, contributes to the destruction of nodes. The tumor shrinks, then disappears altogether. The drug stops even severe bleeding, which provokes the disease. On the nodes affected directly. The treatment carried out by Esmia before surgery prevents the uterus from being removed. Limited to nodes only. If the treatment is carried out accordingly, the monthly cycle will recover quickly enough.

Application, contraindications

According to the instructions, Esmia should be administered before the surgical treatment of uterine fibroids. It is used by women of reproductive age for about 3 months. Self-pill without the recommendation of a doctor is prohibited.

Taking pills start at 1 week of the menstrual cycle. 1 tablet per day. When you skip 1 tablet with a period of not more than 12 hours, the next tablet is taken as quickly as possible. If more than 12 hours have passed, the pill is passed. Women with renal insufficiency dose adjustment is carried out in consultation with the doctor.

Contraindications to the use of funds are:

  • individual intolerance,
  • age up to 18 years
  • pregnancy, breastfeeding,
  • severe bronchial asthma,
  • crayfish,
  • vaginal bleeding not caused by myoma.

A woman should be prepared for the fact that the tool causes a lot of side effects. The whole body is under stress.

  • Mental disorders
  • Headache, dizziness,
  • Nausea, vomiting,
  • Weight gain
  • Vaginal bleeding, nasal,
  • Urinary incontinence,
  • Amenorrhea,
  • Pain in the muscles, joints,
  • Cyst rupture
  • Allergic manifestations on the skin.

Before you start taking the drug, you must tell about all the medicines that were taken before. Some drugs are incompatible with Esmia. About 10 days after the start of the reception there is increased bleeding.

In pharmacies, the drug is available on prescription. The price on Internet sites ranges from 8 thousand to 10 thousand rubles.

Reviews of women from the use of modern drug

“I took the drug according to the doctor’s recommendation. In the pharmacy bought without problems, there is in stock. Saw 3 months. Myoma was of medium size. After the course, the doctor at the reception said that she was gone. Do without surgery. Because of the side effects, my head ached, got fat. Monthly came the next month after the end of the course. Now everything is all right!"

“The neoplasm was larger than average. Developed 16 weeks. She took the drug for 3 months. Put the liver, the result of "0". The blood of 1 month is quite strong, in the second month the daub was, then the blood disappeared. It is not cheap. Spent so much money for nothing. As a result, had surgery. The childbearing function is preserved, but the birth is only a cesarean section. ”

“Saw the drug during the year 3 times for 3 months. Used up 10 packs. The amount of round gone. After the abolition of abundant menstruation returned again. Myoma has grown over all this time by 4 cm. As a result, an operation was performed. I keep quiet about efficiency! ”

“A tumor appeared, began to look for a way out of the situation. At that time, the operation was not discussed. The doctor advised this new drug. Saw 3 months, as expected. On the ultrasound was surprised, myoma decreased, the nodes disappeared. The doctor prescribed a second course. I think the result is obvious! ”

A few words about uterine myoma

Before you figure out how the pills on myoma, you need to know what kind of pathology.

It has been proven that uterine fibroids are benign hormone-dependent formations that occur in the muscular wall of this organ and constitute a tight knot. Myomatous nodes can be single, but more often they are multiple.

The picture shows the types of myomatous nodes, depending on their localization.

The main types of fibroids:

  • Submucous or submucous (when the node is located under the mucous membrane of the uterus and grows into the lumen of the uterus, deforming it),
  • Subserous (myomatous nodes are located under the outer layer of the uterus or grow on its surface, making the uterus hilly),
  • Intramural, or interstitial (nodes located in the thickness of the muscle layer of the uterus).

And this is what a large uterine myoma looks like.

The photo shows the macropreparation of the remote uterus, which is “stuffed” with nodes of different localization.

Myoma is a tumor of the uterus, but the tumor is benign. It grows constantly, sometimes it reaches a huge size and can grow larger than the uterus. But myoma almost never goes into cancer.

Symptoms of the disease

The severity of clinical symptoms depends on the number and location of nodes, as well as the extent to which uterine fibroids have grown.

It should be said that in one third of the patients, uterine fibroids have no symptoms at all. Women do not show any complaints, and myoma is detected by chance with a pelvic ultrasound. For such women, if they are not disturbed by anything, and fibroids do not increase in size, it is recommended that they be regularly monitored by a gynecologist once every 6 months.

Alas, in most cases, fibroids still cause a lot of trouble. With this disease, the uterus can reach large sizes, increasing to 16 weeks of pregnancy, or even more. This tumor does not pose a threat to life, but with a considerable size it can lead to squeezing of neighboring organs, disrupt urination and the bowels, and cause pain during sexual intercourse. Myoma itself is rarely the cause of female infertility, but can lead to miscarriage of pregnancy - repeated miscarriages at different times.

The most frequent manifestation of uterine fibroids - heavy and prolonged bleeding, leading to the development of secondary iron deficiency anemia and pain in the lower abdomen. As a rule, such bleeding is characteristic of submucous myomatous nodes.

The intensity of lower abdominal pain depends on the size, type and location of the node. The main causes of pain are: compression of neighboring organs with myoma, impaired rejection of the endometrium, and hormonal disruptions.

A few years ago with myoma there was only one way out - an operation. Together with the nodes, the uterus was removed by the women, so they could no longer have children. Today everything has changed. The main strategy of modern gynecology in the treatment of benign tumors of the uterus - organ-sparing approach. This became possible when a new medicine for fibroids, Esmia, appeared on the pharmaceutical market.

Treatment options for uterine fibroids

Currently, patients with myoma are not immediately offered a radical surgical treatment. If there is a chance, and the woman wants to preserve fertility, then myomectomy can be performed by hysteroscopic or laparoscopic access, removing only the nodes and preserving the genital organ.

Removal of uterine fibroids with laparascopic access (through small punctures in the abdomen).

The uterine artery embolization (EMA) is used as an alternative to the surgical method. But since this high-tech method requires expensive equipment and highly qualified specialists, it is not widely used. However, EMA is used in leading clinics in Moscow and St. Petersburg, in large regional centers of Russia, and can be recommended for patients who have been diagnosed with uterine fibroids.

The essence of uterine artery embolization is through a catheter into the vessels that feed the node, special substances - emboli, which block the blood flow of the node, which contributes to its regression.

Also, the increasing popularity of drug therapy is gaining, but more often as a preoperative preparation for organ-sparing surgery. This will be discussed in this article.

So, modern approaches to the treatment of benign tumors of the uterus are strictly individual and depend on several factors. When the doctor has to choose a method of treatment, he considers the following key points:

  • Woman's age
  • The severity of symptoms (bleeding, pain, dysfunction of neighboring organs),
  • Sizes and localization of nodes
  • Infertility or miscarriage,
  • The desire to preserve the uterus and realize its reproductive function,
  • Opportunities for hormone therapy.

"Esmia" - a drug for "management" of uterine myoma

The origin of fibroids still remains a reason for scientific discussions. But more recently, it has been established that one of the key growth factors for myomatous nodes is one of the female sex hormones - progesterone. Myoma nodes are very susceptible to this hormone because there are progesterone receptors in their cells.

It is also useful to read: Features of the development of uterine myomatosis

This discovery was the impetus for the creation of a new class of drugs - progesterone receptor blockers in fibroid cells. In pharmacology, such drugs are called progesterone receptor selective modulators (SMPR). The first known representative of this group is the drug Esmia.

When ingested, Esmia penetrates the myoma node and selectively binds to intracellular progesterone receptors, thereby blocking the action of this hormone. This happens with the help of the active substance ulipristal acetate. In addition, this drug acts on other organs.

The effect of Esmia on the body is the following: reduction of myoma nodes, absence of hot flashes due to the effect on the pituitary gland, reduction and cessation of uterine bleeding due to changes in the structure of the endometrium.

So, Esmia has a direct impact on three types of target tissues:

Myomatous nodes

Blocking progesterone receptors in the tumor nodes, the drug inhibits its growth. It causes apoptosis (accelerates the death of old cells) and does not allow the growth of new (that is, inhibits proliferation).

Ulipristal acetate, acting on the pituitary gland, inhibits progesterone activity by reducing the level of luteinizing (LH) and follicle-stimulating (FSH) hormones, while maintaining the estrogen concentration at a normal level. This is very important so that women do not experience hot flashes, which are in the treatment of other drugs.

Also, due to the direct action on the pituitary, Esmia inhibits ovulation, which causes amenorrhea and complete cessation of bleeding.

Endometrium

The third target tissue on which ulipristal acts is the endometrium. This leads to a rapid reduction and even complete cessation of intrauterine bleeding. The bleeding disappears on the 4-7th day of taking the drug and continues to be absent throughout the course of treatment. After the end of therapy, the menstrual cycle is restored and returns to normal after 3-4 weeks.

After cessation of taking Esmia, the first menstruation begins after 4 weeks, and the next cycle is possible full ovulation.

Such action "Esmia" has on all types of myomas, regardless of their size and location. Course therapy provides a decrease in the volume of nodes, the control of heavy menstruation caused by myoma. The drug not only triggers the reverse development of the symptoms of the disease, but also retains its effect after the end of treatment.

Opinion of experts about the drug

The CEO of Gedeon Richter, researchers in the field of evidence-based medicine and practical doctors agree that Esmia is effective, safe and has a positive effect on the quality of life of patients. Before the appearance of this drug, women who were diagnosed with fibroids had no treatment options other than the removal of the uterus. This caused a serious psychological trauma to the patients.

Treatment of uterine fibroids with pills does not always mean a complete rejection of the operation. With their help, you can only delay surgery.

The drug "Esmia" helps the doctor and patient to gain time and choose the most appropriate and gentle method of surgical intervention. This is required in cases where heavy uterine bleeding leads to a decrease in the level of hemoglobin and the development of anemia, because even mild anemia is associated with a risk of postoperative complications up to death.

Reception of ulipristal acetate causes hemostasis in the first 4-7 days of therapy, contributing, together with the use of iron preparations, to the complete relief of anemia. It also leads to a reduction in the size of myoma nodes after 13 weeks of treatment.

After this preparation, an organ-preserving operation can be performed (leave the uterus, removing only the tumor) with minimal risk of complications. After the course of treatment, the fibroids are reduced in size, become more contoured, and during surgery the surgeon is much easier to remove them.

Practice shows that in some cases the course of treatment with ulipristal makes it possible to completely avoid surgery where uterus has been previously planned.

In some cases, after a course of treatment with Esmi on ultrasound, you can see a positive trend in reducing the size of fibroids.

As soon as they call today the discovery of ulipristal acetate: a new era in the conservative treatment of myomas, and a tool to manage tumor growth. In general, drug therapy for fibroids should be aimed at slowing the growth of nodes, reducing the size of the uterus, stopping uterine bleeding and relieving anemia. All these requirements correspond to the modern drug "Esmia".

Perhaps the only drawback of the drug is the high price. The cost of one package (5 mg, 28 pcs.) In Moscow is on average 8-10 thousand rubles. Consequently, one course of treatment will cost 30 thousand rubles, and two - 60 thousand rubles.

The life of many of our contemporaries is formed in such a way that they do not have time to realize their reproductive function in time, postponing the birth of a child "for later". У таких женщин медикаментозное лечение миомы с помощью препарата «Эсмия» позволяет отсрочить операцию, уменьшить объем вмешательства, сохранить матку.

Как принимать лекарство?

Излишне говорить, что препарат «Эсмия» назначается и принимается под контролем врача после полного обследования.

One course of treatment is for 3 months. Taking the tablets is carried out daily in 5 mg, starting from the first week of menstrual bleeding. The drug is taken regardless of food and time of day, drinking plenty of water. A woman chooses a convenient reception time.

The course of the drug is designed for 3 months, after which a break for 2 months, and then, if necessary, is repeated.

If there was a pass in taking the pills and from that moment less than 12 hours passed, the missed pill is taken as soon as the woman remembers about her. In the event that more than 12 hours have passed since the last pill, the missed pill is not taken, and the drug is continued as before.

It is also useful to read: The use of herbs in the treatment of uterine fibroids

Allowed for use in women over 18 with moderate or severe symptoms. For treatment requires 2 courses for 3 months.

Indications for use of "Esmea"

"Esmia" is assigned in such situations:

  • Preoperative preparation of women of reproductive age (18 years) with severe signs of uterine fibroids (abundant, prolonged menstruation, low hemoglobin levels),
  • Course treatment for symptoms of uterine fibroids of moderate and severe in women in the premenopausal period in order to gain time before the onset of natural menopause, when a hormone-dependent tumor undergoes reverse development and surgery may no longer be necessary.

Contraindications

"Esmia" is not assigned under these conditions:

  • Pregnancy and lactation period,
  • Bleeding from the genital tract, the origin of which is not related to uterine myoma,
  • Age under 18,
  • Cancer of the uterus, ovaries, cervix and breast,
  • Bronchial asthma,
  • When renal and hepatic failure is applied with caution.

Since the drug "Esmia" directly interferes with the work of the body's hormonal system, it is necessary to carefully study the contraindications to the use and possible side effects.

Side effects

Against the background of the use of "Esmey" such side effects may occur:

  • Amenorrhea (complete cessation of bleeding and menstruation) is acceptable and desirable,
  • Tides - their severity is so insignificant that it does not require any correction, they pass on their own,
  • Headache,
  • Weight gain
  • Nausea,
  • Muscle and bone pain,
  • Fatigue

Clinical trials have shown that the severity of unwanted side effects when using the drug is insignificant and decreases with subsequent courses of administration. In most cases, this tool is tolerated by women quite well, and side effects do not occur as often as indicated in the instructions for use.

Is it possible to use Esmia in adenomyosis?

Yes, there is evidence of the effectiveness of ulipristal acetate in adenomyosis.

It is known that uterine fibroids are often combined with endometriosis. These diseases have common mechanisms for the development of the pathological process, which determines the similarity of approaches to their therapy.

In adenomyosis, endometrial cells multiply outside the uterine lining. The disease is hormone-dependent and its development occurs in violation of the activity of the immune system.

Experts recommend the use of the new drug Esmia for the treatment of uterine fibroids in combination with adenomyosis.

Other drugs for myoma

Esmia is not the only medicine that blocks progesterone receptors present in uterine fibroids. A similar effect is in the drug "Ginestryl".

“Ginestryl” also has an anti-progestogenic effect, as well as “Esmia”. The active substance contained in “Ginestril” (mifepristone) is able to suppress tumor growth, but less effectively than uliprystala acetate. Mifepristone is completely ineffective with large myomas.

Despite the low cost, “Ginestryl” was not widely used for the drug therapy of uterine fibroids. The dose of mifepristone recommended for treatment can lead to hyperplasia (thickening) of the endometrium and cause uterine bleeding, further aggravating the situation.

In addition to "Esmi" there are other drugs used in the treatment of fibroids, including Mifepristone, Ginestril, Miropriston.

A slight decrease in the size of myoma nodes, along with a hyperplastic process and uterine bleeding against the background of long-term use of “Ginestril”, makes it necessary to make a choice not in his favor. The drug "Ginestryl" is not recommended for widespread use in uterine myoma.

Case report

Patient K., 25 years old, in June 2015, applied to one of the leading Moscow clinics with complaints of prolonged, heavy and painful periods, marked weakness and dizziness, as well as an increase in the size of the abdomen.

A woman told that two years ago, an atypically located uterine myoma (a small intramural node 15 mm in diameter on the front wall of the uterus closer to the cervix) was found on her pelvic ultrasound. The patient had no births, but at that time she didn’t plan a pregnancy. Used barrier contraception.

A year later, in June 2014, during the control ultrasound, myoma node was growing to 6 cm in diameter. Since then, the woman began to be bothered by painful and heavy periods, as a result of which anemia of a moderate degree appeared, the hemoglobin decreased to 85-90 g / l. During the year, the condition worsened: the bleeding increased, the anemia progressed, and the stomach began to grow.

Upon admission to the clinic in June 2015, there is a significant increase in the size of the abdomen due to a dense and sedentary tumor formation of about 20 cm in diameter. An ultrasound study confirmed the presence of the cervical myoma node 18 cm in diameter, which occupies the entire pelvis. A blood test revealed severe anemia - hemoglobin 65 g / l.

The patient received a blood transfusion and hemostatic therapy. After that, the drug “Esmia” was prescribed according to the standard scheme - 1 tablet (5 mg) daily for 3 months.

After 3 days, the patient K. was discharged from the clinic with recommendations: follow the hemoglobin parameters, take iron and ulipristal acetate. The control ultrasound was scheduled after 2 months, followed by planning of an organ-preserving operation.

In September 2015, K. was admitted to the clinic for elective surgery. The use of the drug "Esmia" gave a positive result: it helped to stop the bleeding and amenorrhea, as well as the normalization of red blood parameters - the hemoglobin level increased to 120 g / l. According to the results of ultrasound, the node size changed slightly.

Reception "Esme" was discontinued on the day of surgery. The operation itself was performed by laparotomic access under endotracheal anesthesia.

During surgery, it was found that the body of the uterus is not changed. The entire pelvis was occupied by a myoma node emanating from the cervix (namely, from the isthmus), about 20 cm in diameter. With minor technical difficulties, a huge tumor was removed, and the uterus was saved. Blood loss was 200 ml. There were no complications in the postoperative period. The patient was discharged from the hospital on the 7th day in a satisfactory condition. The result of the histological conclusion: the site of leiomyoma with malnutrition.

3 weeks after the operation, K. started another menstruation (as a reaction to the abolition of the “Esmea”). Menstrual bleeding was painless and moderate.

On the recommendation of the gynecologist, the patient took hormonal contraceptives for 6 months. In April 2016, after the abolition of birth control pills, the desired pregnancy began, which proceeded without pathology. In January 2017, K. was given birth by caesarean section for a period of 38 weeks as a live full-term boy.

This clinical case convincingly proves the efficacy and safety of the use of ulipristal acetate in order to prepare for organ-sparing surgery.

Uterine fibroids - not a sentence

In conclusion of our conversation, we want to say to all women: if you have a uterine fibroid, you do not need to lose composure and faint with the words: “Ah! I have a tumor! ”In our time, uterine fibroids are amenable to conservative treatment and organ-preserving operations are performed, after which you can bear and give birth to healthy babies.

General information about the drug Esmia

The main indication for the appointment of Esmia is uterine fibroids with pronounced symptoms:

  • prolonged heavy bleeding leading to severe anemia,
  • severe pain,
  • dysfunction of adjacent organs due to tumor pressure.

Uterine fibroids are benign tumors and develops in women of reproductive age 30-45 years. The main role in the change of the muscular layer of the uterus is played by hormonal disorders in the body, with the predominance of estrogen and progesterone receptors in the diseased tissue.

Unfortunately, they often resort to treatment by surgery, or by removing the nodes or the body of the uterus. But not bad results can be achieved using the drug method.

For many years, GnRH agonists have been used for this purpose, which affect the functioning of the pituitary-ovary system and correct the effect of sex hormones on the uterus. But this group of drugs has a number of frequently occurring side effects, is used in the form of injections and is mainly used before the operation, since after 2-3 months the nodes return to their original size.

Therefore, in recent years preference has been given to a safer and more effective group of selective modulators of progesterone receptors. These substances include ulipristal acetate, which is part of the drug Esmia.

The mechanism of action is as follows:

  • due to the similar effect with progesterone, its production in the body decreases,
  • at the same time, the connection of progesterone circulating in the bloodstream with receptors in the uterus is blocked,
  • A distinctive feature of the drug is the absence of a decrease in estrogen.

To achieve a therapeutic effect, Esmia is taken 1 tablet (5 mg of ulipristal acetate) 1 time per day at the same time, regardless of the meal. The drug is rapidly absorbed, binds to plasma proteins and is excreted mainly through the intestines.

The drug begins to drink from the first week of the menstrual cycle, that is, in the first days of menstruation. Of course, you need to be careful and drink according to the schedule, but when you skip the pill, you should immediately drink it, as you remember. If too much time has passed (more than 12 hours), then forget about the missed pill and continue as usual.

The effect of Esmea on the menstrual cycle

Already in the first week of therapy, menstrual bleeding decreases in volume and stops after 7-10 days, which also increases the effectiveness of drugs for the treatment of anemia. Normally, subsequent menstruation does not occur.

The duration of one course of treatment is three months. A second course can be held after two menstrual cycles. It is recommended to drink not more than 2 courses, as there is no sufficient data on the effect of the drug on the endometrium during prolonged use.

In some cases, before surgery, the appointment of an additional 3rd year course is not excluded. This is due to the detrimental effect of the drug on the tumor cells, which leads to a reduction in the size of the formation, and this facilitates access during the operation.

As with any drug, there are a number of contraindications that must be considered when prescribing:

  • the cause of the bleeding from the vagina is not clear
  • malignant neoplasms of the internal genital organs, mammary gland,
  • severe bronchial asthma,
  • severe renal or hepatic failure
  • allergic reaction,
  • age of women under 18 years old.

During pregnancy and during breastfeeding, the drug is not recommended, as there have been no studies on the effects on the human embryo or the penetration of the drug into breast milk.

How does Esmia in uterine myoma affect the monthly cycle

According to the recommendations of the European medical community, we suspend the further prescription of the drug Esmia to patients with uterine fibroids until the causes of isolated cases of toxic effects of the drug on the liver are identified. Learn more.

Esmia and uterine fibroids are directly related, since when the drug is taken, the formation of the endometriotic layer of the uterus stops. The drug directly affects the formation of the endometrial layer. Thus, a woman stops monthly bleeding for the entire duration of the drug. In the first month of bleeding may be scarce, then stop altogether. This is due to the fact that, since the endometrial layer is not formed, there is nothing to reject every month. In fact, a woman is introduced into an artificial, reversible menopause.

Treatment of uterine fibroids Esmia lasts for 3 months. In rare cases, the course may be extended for a longer period. Sometimes you need to undergo a repeated three-month course.

After the drug Esmia is canceled, after 4 weeks, the menstrual cycle is fully restored. A month later, another menstruation comes, and after two months, the ovulatory cycle resumes.

Myoma after Esmia

In most cases, this drug is used as a preoperative preparation, since Esmia not only reduces the blood supply to the uterus and thus makes the operation safer, but also reduces the size of the nodes, as well as making them more contoured, which makes it easier for the doctor to remove them. As therapy for uterine fibroids, Esmia is used mainly for small nodes, or in cases where a woman is on the verge of menopause - that is, in the late reproductive age. In such cases, the drug is prescribed to relieve the woman from bleeding and pain. Upon the onset of menopause, myoma nodes regress and gradually disappear completely.

How does Esmia on the woman's body

Esmia has a direct effect on the endometrium of the uterus. With a daily intake of 5 mg from the first day of menstruation, for 4-5 days, women had marked the end of menstrual bleeding, with no monthly periods for the next month. After stopping the medication, the periods were restored after 4 weeks. Such an effect of the drug is associated with a specific direct effect on the endometrium, which is expressed in an antagonistic effect on the progesterone receptors. Its action is expressed in the change of the epithelium - it becomes weak and inactive. Such changes were noted in 60% of women who used Esmea for 3 months.

Esmia has a direct effect on uterine myoma, causing apoptosis and cell proliferation, which in turn leads to a decrease in myomatous nodes.

In addition, the drug for daily use of 5 mg affects the pituitary gland - suppressing ovulation.

Security Studies of Esmea

In the study of Esmea, it was found that the drug with long-term use or when exceeding the dose is not toxic to humans. In studies on animals, it was found that the active substance of Esmia - ulipristal, can lead to fetal death; there are no data on the effect on the human embryo, since no such studies have been carried out. When testing the drug in animals, there was also no evidence of the effect of Esmea on the reproductive ability of individuals taking the drug in the same doses and with the same regularity as humans.

Pills for uterine fibroids Esmia - efficacy and safety

A study was conducted on the effect of the drug on women with severe and painful menstrual bleeding that was caused by myoma. Patients were given both doses of 5 mg and 10 mg once a day.

In the group in which women took Esmia, they found a significant decrease in menstrual bleeding that occurred during the first week of taking the drug. There was no such result among the placebo group.

In addition, as shown by MRI studies, the size of myomatous nodes significantly decreased in women who received Esmia. The same data was obtained during an ultrasound examination, in women who did not undergo hysterectomy, after undergoing a course (13 weeks) there was a decrease in fibroids and this effect persisted for another 25 weeks after undergoing a course of treatment, while patients who received other drugs of similar effect a slight increase in myoma nodes was noted.

Another study was conducted in which women took 2 three-month courses, receiving the drug in a dose of 10 mg. A decrease in bleeding and volume of myomatous nodes was also noted during this study. Considering the data obtained, it can be stated that Esmia is not only effective, but also a safe preparation.

Esmy instructions for use in myoma

In order to get the maximum effect when taking the drug, you must take it strictly as directed by your doctor. Only a doctor will be able to determine the required dosage according to the history and associated diseases. Так как терапия Эсмия является достаточно длительной – иногда курс лечения может длиться до трех месяце, в период лечения дозировка может корректироваться в зависимости от побочных эффектов, переносимости препарата и реакции миоматозных узлов на лечение. Обычно женщинам назначается препарат в дозировки 5 или 10 мг один раз в сутки. Предпочтительно принимать Эсмию в одно и то же время во второй половине дня. Прием препарата никак не связан с приемами пищи, поэтому принимать его можно как до еды, так и после.If the patient has a severe reaction to the drug, the doctor can reduce the dose or cancel the drug.

Causes and characteristics of the disease

Why in fact there is no healthy division and cell growth in the uterus has not yet been established by science. However, there are a number of factors that contribute to the development of tumors. These include the following:

  • A sharp restructuring of the hormonal background
  • Hereditary predisposition
  • Various infectious diseases of the reproductive system

  • Injuries associated with the pelvic organs
  • Chronic irregular menstrual cycle
  • Increased body mass index and obesity
  • Any pathology in the field of the cardiovascular and endocrine systems

During active tumor growth, patients may experience the following symptoms:

  • Severe bleeding between menstruation.
  • Failures in the cycle of critical days

  • Pain and aching sensations in the abdomen
  • Disruption of the bowels and bladder
  • Gradual increase in the abdomen as during pregnancy

If you carefully listen to your body, then do not miss the alarm bells about the beginning of the pathological process.

How is uterine fibroids treated

Depending on the type of neoplasm, its size, the state of the tissue and after a complete diagnosis of the patient, the doctor prescribes an individual course of therapy. At the initial stage, myoma is usually not touched, but just regularly monitored for it. If the disease progresses, then hormone preparations are prescribed with an additional course of herbal medicine.

When the state of the tumor is deplorable, there are malignant changes in the cells or a sharp growth of the nodes begins, then the fibroid is removed from the body surgically. The latter method causes fear and psychological stress in women, because as a result of the operation, you can be left completely without a uterus, if the disease was neglected.

But medicine does not stand still, and the leading Hungarian pharmaceutical company Gedeon Richter in 2014 released the latest hormonal drug Esmia.

This unique medicine in a few years saved hundreds of women from surgical operations and helped them to keep the uterus in their bodies. Let's see why this tool has received such a huge number of positive feedback from patients and gynecologists.

Description of the drug, its properties and advantages over other medicines

Esmia is a hormonal, anti-progestogenic drug. It contains patented substance. sprinkled acetatewhich has a direct effect on myomatous nodes. It suppresses the pathological proliferation of tumor tissues and causes cell death.

As a result of this directional action, the neoplasm is reduced in size. This property is also used in the preoperative period to improve the condition of patients and reduce the scope of the surgical intervention itself.

The drug has undergone numerous overseas clinical studies. Their results proved the high efficacy of the remedy for uterine bleeding.

Esmia quickly stops excess blood excretion and helps regulate anemia. Compared to GnRH agonists, the new drug has several advantages:

  • Suppresses the action of progesterone receptors, thereby reducing the level of the hormone in the blood, and fibroids cease to develop.
  • It has an effect on the pituitary gland, as a result has a pronounced contraceptive effect.
  • Does not cause a drop in estrogen levels, a decrease in bone density and a decrease in libido.
  • It does not affect a healthy myometrium, but acts selectively only on abnormal cells.
  • It has an antimicrobial effect, which has a positive effect on concomitant infectious diseases.
  • Stops even severe uterine bleeding, which leads to a decrease in pain in the pelvic region and the elimination of iron deficiency anemia.

  • Returns to women the ability to conceive and maintain a comfortable lifestyle.
  • The therapeutic effect of the drug is cumulative and lasts for at least 6 months after discontinuation.
  • In most cases, it is well tolerated and causes a minimum of side effects.

Despite all the benefits of taking Esmia, treatment must be controlled. Such a medical therapy can be prescribed only by a doctor after a full diagnosis of the disease and the completion of all tests. Self-treatment is not permissible, as it can lead to irreversible effects in the body.

Release form and composition

The drug is a pill for internal use. They have a biconvex rounded shape, white color and engraving "ES5" on one side.

These features are designed to protect the drug from fraud. If you are in doubt about the properties of the purchased product, ask the pharmacy to present you a quality certificate, the staff must provide it upon the first request of the client.

The tablets are packaged in blisters of 28 pieces. One package of the drug Esmia No. 28 costs approximately 8 500 rub, in different cities the price may differ.

1 tablet contains 5 mg of ulipristal acetate, as well as excipients: mannitol, microcrystalline cellulose, talc, magnesium stearate and croscarmellose sodium.

Who is assigned to Esmia and how to take it

The pills for Esmy fibroids are shown to all women over 18 years old who have moderate and severe uterus pathology, as well as to patients before surgery to remove the tumor.

The instructions for use say about the need to take the drug course in 3 months, which can be repeated if necessary after a 2-month break.

This means that in total you will need 84 pills in the first period, and after the break you may need to buy 84 more. The total cost of treatment will cost about 50 000 rub.

The daily dose of the drug is 5 mg, i.e. Take 1 tablet per day, regardless of the meal.

It is necessary to begin therapy in the first week of a menstrual cycle. It is necessary to drink the medicine strictly at the same time every day in order for the active substance to maintain its concentration in the blood.

If you have missed taking hormone for forgetfulness, drink it as quickly as possible within 12 hours. When the time limit has already been exceeded, then the use of this hormone is simply skipped and the course continues.

Therapy with Esmia is prescribed exclusively by a gynecologist after a complete examination of uterine fibroids.

If the completed treatment does not give the expected effect and myomatous nodes do not decrease in size, then a decision is made about the operation of the neoplasm. However, in most cases, reviews of patients on the use of the hormone drug Esmia with myoma show positive results. Let's look at a few such examples below.

Lyudmila, 34 years old

“Half a year ago, the doctor on a routine inspection diagnosed me with uterine fibroids. I went through all the necessary examination procedures and passed the tests. After that, I was prescribed treatment with Esmy. I saw him as much as 3 months. I did not notice any side effects, although there was some irritability and occasional insomnia, but it happens to me in ordinary life.

At the next visit after the end of the course I learned that the tumor had halved! Now I hope that the operation can be avoided. I also think about pregnancy. But the doctor says, so far nothing has been planned. The treatment is certainly not cheap, but the result is worth it! ”

Nadezhda, 37 years old

“I want to leave a review about the treatment with Esmia. 4 years ago, I was diagnosed with uterine fibroids 1 cm in size. The doctor began to monitor her, but did not prescribe any treatment. After 2 years on ultrasound, it turned out that the tumor had increased dramatically to 9 cm, and the second one also grew 4 cm.

I was very worried then. The uterus was warped to the same. I went to many specialists, everyone said that the operation was inevitable. But the last doctor suggested that I try to drink a course of the hormone drug Esmia. I took these pills all summer. Menstruation did not stop, although the doctor said that she should stop. But the profusion of bleeding decreased markedly and the pain decreased. There were many side effects: hot flashes, fullness, fatigue, drowsiness. By the end of the treatment, the back became very sick. I even had to interrupt work for a while due to poor health.

This is of course a big disadvantage of such an expensive treatment.

But as a result, in the autumn I was told by an ultrasound that the first tumor had decreased by 1 cm, the second one by almost 2 cm! Recently decided on a second course.

She started taking the drug and immediately felt all the side "joy." I go forever sleepy, my back hurts along the spine, there are severe dizziness. But I really hope for a positive effect from the treatment! ”

Evgenia, 45 years old

“I also decided to share my experience with this drug. A year ago, in our local clinic at the routine examination, the doctor discovered myoma. I was shocked. The gynecologist said that if the tumor starts to grow, they will operate with precision.

I returned to the hospital after 3 months, I was already admitted by another gynecologist and found that myoma increased. But he offered me not an operation, but the hormonal drug Esmia. At home, I began to look for information about this medicine, I read many different horrors. But still I bought the pills and started the course. Of the negative symptoms, I didn’t have anything, although many write the opposite. After 3 months I went to a second appointment.

What was my surprise when I heard from a specialist that fibroid decreased by 2 times!

The gynecologist said that it is necessary to repeat another course of therapy with this drug. I naturally agreed. So, girls, Esmia works and helps to avoid surgery! ”

Side effects and contraindications

Despite the positive feedback from women about the normal state during treatment with Esmy, the medication often has side effects. They can manifest as the following symptoms:

  • Headaches and dizziness
  • Feelings of anxiety and irritability
  • Nausea, constipation, abdominal pain
  • High sweating and acne on the skin
  • Pain in the back and muscles
  • Soreness and swelling of the mammary glands
  • Tides and thickening of the endometrium
  • Weight gain
  • Fatigue and sleepiness
  • Edemas

If you find yourself having similar symptoms, be sure to tell your doctor about them.

The occurrence of side effects does not always completely preclude the use of the drug. Consult on this issue with a specialist.

You should not take this medication if you have at least some contraindications. The list of such prohibitions consists of the following items:

  • Individual intolerance of the main active ingredient
  • Age up to 18 years
  • Bleeding from the uterus for an unclear reason
  • Cancer of the cervix, uterus, ovaries or mammary glands
  • Severe bronchial asthma
  • Periods of pregnancy and breastfeeding
  • With caution in the pathology of the liver or kidneys

In any case, despite the large list of contraindications and the frequency of side effects, Esmia is well tolerated compared to other hormonal drugs.

Patient Reviews

Here is what women themselves say about the effectiveness of hormone therapy:

Valeria, 42 years old

“Dear women, I decided to share with you my experience of using the drug Esmia. When I was diagnosed with uterine fibroids and prescribed this expensive treatment, I wondered if I should go for surgery right away? I read a lot of reviews on the Internet. Everyone has everything individually.

Someone tolerates hormones, others suffer with a lot of side effects. The results are also different, but in most cases, it is still impossible to avoid the operation. I tell my story. My fibroid is 6 cm in size and is located on the outside of the uterus. I saw Esmiya 3 months, there were no side effects. The result is also unfortunately. Myoma in size has not decreased, although it has not grown. The attending doctor offered to drink another course, but I do not want. I still think I will have to operate. I will consult with another specialist soon. ”

Daria, 29 years old

“The drug Esmya was prescribed to me by a doctor when I found a myoma on the uterus. I have completely cut a pack of 28 tablets. An ultrasound said that there was a decrease of 1 cm. She continued taking another 2 months.

The side effects were nausea and mild pain in the lower abdomen. The gynecologist answered my questions about this that it was only at the very beginning that such an adaptation to treatment. I ended up with 1 course and have no regrets, because myoma has almost completely disappeared. And I feel great! Therapy flew into me of course a pretty penny. ”

Alina, 36 years old

“Here is my story about the drug treatment Esmy. In the first days of the intake, they often threw heat, muscles ached and there was a malaise like a flu: my head ached and I felt general weakness.

After 2 weeks of treatment, red spots appeared on the skin, apparently an allergy began.

Soon all was covered by them.

After I finished the whole package, I went for an ultrasound. They said that fibroid decreased by only 0.5 cm, and was 7 cm and a cyst formed in the ovary. The second package did not drink, because before that she had surgery when there was an ovarian cyst rupture. Plus, these rashes have tortured. Two weeks later she came to the gynecologist. He told me that myoma again increased by 1 cm.

On the positive side, only that the chest has stopped hurting can be distinguished. Before taking the medicine was very sick. Allergy disappeared only a month after discontinuation of the drug. Here is my experience. Maybe if the entire course had been drunk, there would have been an effect, and now only the operation will go. ”

Veronica, 33 years

“I will share with you a positive experience of taking this drug. The first course I was assigned six months ago, now I drink the second one.

Myoma actually decreases with each passing month, as if being drawn back into the uterus.

There are mostly bad reviews on the Internet, because women forget to write about good results. Passed the disease and great! Do not be afraid to undergo treatment with this drug, I have not even had any side effects, although many of them appear. All individually, consult a doctor! "

What drugs can not take the drug Esmia

Instructions for use clearly indicates that the drug can not be taken simultaneously with other hormonal contraceptives, because they will enhance the effects of each other and may damage the body.

The following medications are also prohibited: Rifampicin, phenytoin, carbamazepine, St. John's wort herb, Digoxin and Dabigatran. Violation of this rule can lead to a dramatic appearance of side effects.

Doctors gynecologists talk about the positive results from treatment with Esmy. If all dosages and rules of admission are followed by the patient, and the diagnosis is made at an early stage, then a good effect will not take long to wait.

Esmia is highly effective and can prevent surgical intervention in the patient's body. A woman can save reproductive organs and have the ability for subsequent childbearing!

Pills for uterine fibroids Esmia - efficacy and safety

A study was conducted on the effect of the drug on women with severe and painful menstrual bleeding that was caused by myoma. Patients were given both doses of 5 mg and 10 mg once a day.

In the group in which women took Esmia, they found a significant decrease in menstrual bleeding that occurred during the first week of taking the drug. There was no such result among the placebo group.

In addition, as shown by MRI studies, the size of myomatous nodes significantly decreased in women who received Esmia. The same data was obtained during an ultrasound examination, in women who did not undergo hysterectomy, after undergoing a course (13 weeks) there was a decrease in fibroids and this effect persisted for another 25 weeks after undergoing a course of treatment, while patients who received other drugs of similar effect a slight increase in myoma nodes was noted.

Another study was conducted in which women took 2 three-month courses, receiving the drug in a dose of 10 mg. A decrease in bleeding and volume of myomatous nodes was also noted during this study. Considering the data obtained, it can be stated that Esmia is not only effective, but also a safe preparation.

Esmia in Endometriosis

Uterine fibroids in many women are accompanied by endometriosis. Since these diseases have a common developmental mechanism, and they both directly depend on the hormonal background of the woman, a common approach is applied to their treatment. Although in the scientific literature there is no data on the studies conducted by Esmia as a therapeutic agent for endometriosis, however, as practice shows, this drug can alleviate the condition of a woman not only with myemost nodes, but also with endometriosis. Particularly relevant is its reception before the operation or for women in the pre-climatic period. В связи с тем, что рост эндометрия при приеме Эсмия практически останавливается, продержать пациентку в стабильном состоянии до наступления естественной менопаузы может стать выходом при тяжелой форме эндометриоза. Однако следует отметить, что определить, нужно ли женщине принимать этот препарат при эндометриозе, может только лечащий врач. Самолечение Эсмия недопустимо, препарат должен приниматься только под строгим контролем врача.

Эсмия отзывы при миоме 2016

Esmia has already become a popular drug, reviews in patients with myoma are positive in most cases, the only drawback is the price of the drug. Its cost ranges from 10 to 15 thousand rubles. However, it is worth noting that, according to reviews, Esmia was able to save the uterus to many women. In addition, operations performed after taking Esmia are less traumatic and safer. However, patients should be aware that Esmia is not a panacea for fibroids. It is impossible to completely cure this pathology - you can only stop its growth and ease the symptoms. Therefore, the feasibility of taking the drug is determined by the doctor, but the decision remains for the patient.

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