Metronidazole is an antimicrobial and antiprotozoal agent. The drug is produced synthetically under the influence of chemical reactions. It does not apply to antibiotics, but has antibacterial properties. The effect of the drug on pathogenic microorganisms was noticed by chance in 1962, when, after taking this remedy to eliminate trichomoniasis, the patient was cured of bacterial gingivitis.
The drug is available in the form of tablets, injections, as well as part of ointments, gels, suppositories. Depending on the type of infection, the physician prescribes the form of the medicine and its dosage. Metronidazole is widely used in various fields of medicine.
The use of metronidazole in gynecology and venereology
The drug is prescribed for the treatment of diseases of the female reproductive system and sexually transmitted diseases. In the presence of venereal pathologies, it is necessary to treat both sexual partners, since one of them may be a carrier of the virus, which does not manifest itself as vivid symptomatology. Otherwise, it may provoke reinfection. In addition, it is recommended to refrain from intimacy during the treatment of STDs.
In venereology, the drug is prescribed if the following ailments were identified:
- infectious and inflammatory diseases of the ovaries,
- other venereal pathologies.
But also Metronidazole helps in the treatment of:
- candidiasis (thrush),
- inflammatory diseases of the pelvic organs,
- violations of the vaginal microflora,
- pathologies of the uterus and fallopian tubes.
Form release Metronidazole for the treatment of female diseases
First of all, the effectiveness of therapy depends on the form of release of the drug and the method of application.
For the treatment of gynecological and sexually transmitted diseases women are most often prescribed tablets, intravenous injections, ointments and suppositories. Depending on the severity of the disease, the physician decides which form of the drug to prescribe to the patient.
Dosing and Administration
Tablets should be taken 2-4 times a day, one at a time (250 mg) after a meal, while squeezing it with plenty of water. It is forbidden to use other drinks: tea, coffee, juice. This may affect the medicinal properties of the drug. The number of tablets per day is determined by the type of infectious disease. With trichomoniasis, the drug must be taken twice in 24 hours for 10 days. For amebiasis or giardiasis, the course of treatment is 5 to 10 days with a daily dosage of three tablets.
In the form of vaginal suppositories or gel, metronidazole (500 mg) is used once a day, overnight for 10 days.
If intravenous injections are prescribed by a doctor, then the course of treatment is determined in each case individually. As a rule, the dropper with the drug is placed every 8-12 hours.
Like any other drug Metronidazole has a number of restrictions for use, which are as follows:
- Hypersensitivity to the drug.
- Lactation period. Since the substance is rapidly absorbed into the patient’s blood and is subsequently excreted with the mother’s milk, experts strongly recommend that breastfeeding be stopped for the duration of the treatment.
- First trimester of pregnancy. Metronidazole quickly and fairly easily penetrates the placenta, which can lead to unpredictable consequences and harm the fetus. In the 2 and 3 trimesters of pregnancy, the use of the drug is possible only if the risk of developing complications of the disease for the mother is higher than for the child.
- It is forbidden to take medication to patients under the age of 18 in combination with Amoxicillin.
- The drug is contraindicated for people with alcohol dependence, suffering from diseases of the gastrointestinal tract, kidneys, liver.
With caution, the drug should be taken by patients who are prone to the development of negative manifestations from taking medication. Metronidazole can cause disruptions in the functioning of various body systems:
- Disorders of the gastrointestinal tract can be expressed as abdominal pain, nausea, vomiting, diarrhea or constipation.
- On the part of the nervous system, such manifestations as headache, dizziness, insomnia, irritability, lethargy are possible.
- It is possible the development of an allergic reaction in the form of itching and rash on the skin, as well as urticaria.
- In rare cases, patients complain of stinging and burning during urination.
The effect of metronidazole on the menstrual cycle
It is a widely accepted opinion among women that this medicine has an effect on the duration and intensity of menstruation. Experts have proven that the drug does not affect menstruation, and all failures are caused by other factors.
Among the causes of violations of the cycle are:
- Inflammatory processes in the pelvic organs.
- Venereal diseases.
- Hard diets.
- Exhausting sports or hard physical labor.
- Stress, depression.
- Hormonal imbalance.
- Sharp weight loss or weight gain.
- Gynecological diseases: cervicitis, adnexitis, uterine myoma, cervical erosion, ovarian cyst, endometriosis, polyps in the reproductive organ or cervical canal.
- Malfunction of the endocrine system.
In addition, upon the onset of hot weather, it is common for critical days to advance prematurely.
The most common cause of delayed menstruation is pregnancy. Therefore, in the absence of menstruation, a woman is recommended to immediately make a test and consult a gynecologist, since Metronidazole is strictly prohibited in the first trimester due to easy passage to the placental barrier. The gynecologist will determine the exact cause of delayed menstruation, prescribe treatment. If pregnancy is confirmed, the doctor will replace Metronidazole with another drug that will not adversely affect the formation of the fetus.
Experts warn that the failure of the menstrual cycle can be a symptom of many dangerous diseases, so do not delay the visit to the gynecologist.
All patients taking Metronidazole are unanimous in the opinion that this drug has a positive effect in the treatment of various infectious diseases. He successfully deals with dermatological ailments (acne, acne), surgical (relieves from purulent inflammations and is prescribed in the postoperative period), diseases of the urinary tract (cystitis) and pathologies of the gastrointestinal tract (duodenal ulcer, colitis, gastritis, abscess of the liver). In addition, the tool is suitable for the treatment of dental diseases (flux, inflammatory processes in the gums), and is also prescribed for alcohol dependence.
The advantages of the drug patients include:
- Low cost. Unlike its import analogue of Trikhopol, the price of Metronidazole is from 12 p. for 20 tablets, and for vaginal suppositories - about 200 p.
- Availability. The medicine can be purchased at any pharmacy.
- Broad spectrum of action. The drug helps to get rid of various types of bacteria. The exceptions are streptococci and staphylococcus.
- Minimal side effects.
- Rapid recovery, which occurs with the simultaneous use of suppositories and tablets for the treatment of gynecological diseases.
Metronidazole is an indispensable tool in the fight against bacteria that infect the human body. Not being an antibiotic, this drug has a wide spectrum of action and successfully copes with a variety of pathogenic microorganisms and viruses. Despite the low price, the drug has a lot of advantages that are more expensive drugs. Metronidazole does not harm the human body, as it acts only on pathogenic bacteria.
Mechanism of action
In order to understand whether the antibiotic affects the menstrual cycle, consider its mechanism of action. In the process of interaction with deoxyribonucleic acids (DNA) of the cells of harmful microorganisms, Metronidazole blocks the production of acids, which causes the death of the bacteria.
As we see, the antibiotic has no effect on the production of hormones in the body of a woman, and, therefore, has nothing to do with menstruation. It provokes the death of the simplest microorganisms, destroying their internal cellular processes.
Metronidazole is produced in several dosage forms:
- vaginal suppositories
The use of tablets and solution have no connection with the monthly and can be used in any period. But candles and gel are used intravaginally, so during menstruation Metronidazole in the form of suppositories and gel is not recommended. This is due to the fact that at this moment the flora in the vagina may change, which will reduce the effectiveness of the antibiotic several times. Therefore, the treatment regimen is calculated so that it ends before the menstruation. Otherwise, pills are prescribed for therapy.
Use in gynecology and venereology
Metronidazole is used to treat the following diseases:
- infectious and inflammatory processes localized in the pelvic organs,
- pathology of the uterus caused by the simplest microorganisms,
- intestinal diseases that can cause the development of genital infections (particularly giardiasis).
The drug has been successfully used to treat a wide range of other infectious and inflammatory diseases. Its powerful antibacterial and antiprotozoal activity allows it to cure very quickly the pathologies caused by bacteria and protozoa that are susceptible to it.
To date, there are no restrictions to use Metronidazole during menstruation in tablet form.
Metronidazole and menstrual cycle
What is the effect of metronidazole on menstruation? This question has been very popular on the Internet lately. And since we found out that antibiotic has no effect on monthly. Let's see what can change the cycle.
Pathologies of the menstrual cycle can cause inflammatory processes of the genital organs. That is, the diseases themselves, for the treatment of which Metronidazole is used, can provoke menstrual disorders in women.
Also, cyclical disorders can cause stress, diet, a sharp increase in physical activity, changes in ambient temperature. For example, most often, with the onset of intense heat, menstrual periods occur a little earlier than usual.
Delay in menstruation after metronidazole can be caused by hormonal imbalance, which occurred due to many reasons. In this case, we must not forget that one of these reasons may be pregnancy. Therefore, during the delay it is very important to determine in time whether the patient is pregnant, since the use of Metronidazole is contraindicated in the first trimester. If pregnancy is confirmed, the antibiotic should be immediately canceled and consult a doctor for advice and possible replacement.
Also, hormonal imbalance can be caused by various endocrine pathologies. Therefore, with a long delay of menstruation, it is necessary to consult with your doctor, who will schedule an examination and conduct a series of tests, to establish an accurate diagnosis.
It is also an absurd proposition that Metronidazole causes monthly. We figured out the mechanism of the drug effect and found out that it has nothing to do with menstruation. The antibiotic disrupts the intracellular synthesis of nucleic acids and thereby causes the death of the causative bacterium. Its action does not affect the production of hormones in the body and the hormones of the patient, and, therefore, can not cause the appearance of menstruation.
Monthly causes can be a variety of violations, the list of which may include the reasons listed above.
When and how does the medicine work?
The medical literature clearly outlines the range of diseases in which gynecologists prescribe this drug to their patients. Since the main advantage of metronidozol, experts believe is its antibacterial and anthelmintic effect, the medicine is prescribed in the following cases:
- The first is the inflammation of the vagina and urethra caused by Trichomonas.
- Intestinal diseases caused by giardia or amoeba. Giardiasis can also provoke various inflammatory processes on the part of the female genital organs.
- Various skin diseases caused by the simplest bacteria, perfectly amenable to treatment ointment form of the drug. Experts note a positive effect from the use of drugs, even with cutaneous leishmaniasis.
- We should not forget about the various pathologies in the ovaries and tubes caused by infection. In the absence of proper therapy, the disease can spread to the kidneys, ureters, and urethra.
- And finally, diseases of the uterus, such as endometritis, caused by the simplest microorganisms.
It says that the composition of the drug does not have the slightest relation to the woman's menstrual cycle and absolutely does not affect the hormonal background of the patient. The drug acts directly on the protozoa and microbes, causing the death of the cells of these microorganisms.
Modern medical research indicates the negative effect of metronidozol on the very reproduction of amoebas, Giardia and Trichomonas, which is the key to the complete recovery of patients taking this medicine. In addition, gynecologists note that this tool tends to accumulate in the tissues and fluids of the human body, which creates a protective background from re-infection for quite a long time.
Forms of the drug for the treatment of female pathologies
Modern pharmacology recommends that patients for the treatment of inflammation and intestinal problems caused by protozoa, several dosage forms of metronidazole. Each of them is appointed by the doctor in the presence of a certain pathology in the lady. Quite often, these forms are combined in one treatment course.
We recommend reading an article on the treatment of bacterial vaginosis. From it you will learn about the disease and its causes, the impact on the cycle and menstruation, therapies.
Solution for intravenous administration
This form of the drug is used in case of severe inflammatory diseases or to prevent various effects during surgical interventions on the pelvic and abdominal organs.
Given the rate of absorption of metronidazole in the patient's blood, the next reception can not be carried out earlier than after 8 hours. This rule is taken into account in the gynecological hospital in the appointment of complex therapy.
There are several features in the treatment of inflammatory processes with a solution of the drug. In the first, the rate of drug administration should be 1 ml per second, and secondly, when using solutions other dosage forms are not used. This will help avoid overdose of the drug.
Often patients worry if metronidazole can be given during menstruation. If the drug is used in solution, it means that the patient’s condition causes concern, so any interruption in treatment may adversely affect the health of the woman.
This form of the drug is quite popular among specialists, as it allows you to act directly on the inflammatory process in the female genital organs or intestines. Each candle contains up to 500 mg of active ingredient.
A distinctive feature of this medical form is the low probability of overdose of the drug or the occurrence of pronounced side effects. This positive trait of vaginal suppositories is due to the fact that the medicine in smaller doses enters the bloodstream of the patient.
Usually the treatment period lasts from 7 to 14 days. The pharmaceutical package contains 7 suppositories, which is quite convenient for a woman.
Candles metronidazole during menstruation prefer not to appoint, because under the influence of the changed flora of the vagina and under the influence of the outgoing blood, their therapeutic effect decreases several times. Therefore, the strategy of treating the inflammatory process is built so that during the period of monthly bleeding the use of this form of the drug can be completed and, if necessary, transferred to tablets.
According to experts, this dosage form of the drug is the most common for the treatment of protozoa microbes in the female body. Each tablet contains 250 mg of drug substance.
Basically, they are used by experts for the treatment of female genitalia, and for the treatment of bowel disease. Если пациентку мучают кишечные паразиты или глисты, то обычно рекомендуют в течение недели принимать по 2 таблетки 3 раза в сутки.
Но подобный график хорош при отсутствии выраженных симптомов. If amebic intestinal damage has become chronic, the dose of the drug is increased to 2 grams per day, and the treatment period is prolonged twice.
Also, the drug tablets prescribed in the diagnosis of trichomoniasis. This disease is treated by a course of 10 to 12 days in a dose of 250 mg. You can try to speed up the process. In this case, the dose should be doubled and, if necessary, to enhance the effect of the drug by intravenous administration of metronidazole.
Good results show tablets in the treatment of ureaplasmosis. This microbial pathology is perfectly suppressed by 2 tablets per day.
Look at the video about the drug:
Creams and ointments
The modern pharmacological industry has developed a special form for the treatment of skin manifestations of pathology in a woman caused by protozoa. Most often, this dosage form is used to treat inflammatory diseases of the vagina and external genital organs.
The course of medical intervention should not exceed a week. At this time, 5 grams of the medicine is applied to the affected skin. A similar procedure is usually carried out twice a day.
Some patients believe that metronidazole causes menstruation. External use of the drug does not affect the woman's menstrual cycle, and even if the drug is injected directly into the vagina, it does not affect the onset of menstruation.
What should a woman fear when receiving
Most experts refer this drug to the number of drugs with low toxic effect. According to the doctors, taking this drug most often causes:
- Disorders of the digestive system. Patients noted dryness of the oral mucosa, nausea, urge to vomit, recurrent pain in the stomach and intestines.
- Common allergic reactions are possible, such as dermatitis, swelling of the nose and throat, increased body temperature, and difficulty breathing.
- Often the drug is reflected in the work of the urogenital system. Possible urination, retention or incontinence.
- Some experts describe problems with the central nervous system in these patients. There may be headaches, sleep disorders and changes in the perception of the world. Similar symptoms usually occur with long-term medication.
If a woman took metronidazole and a delay in menstruation has arisen, you should not link these two points. Doctors say when taking the drug thrush, a violation of the coagulation system, possible pain in the joints, but there is practically no failure of the cycle. Such symptoms are simply a coincidence, as the drug is used to treat inflammatory diseases of the genital organs, which in itself can cause menstrual disorders.
We recommend reading the article on menstruation with endometritis. From it you will learn about the causes of the disease and its effect on the menstrual cycle, the treatment of endometritis with metronidazole and other drugs.
How does metronidazole affect the menstrual cycle
If you carefully read the annotation to the drug, you can see that menstruation is not a reason to stop treatment. Moreover, many gynecologists are confident that a break in the use of medications can adversely affect a woman’s health and negate all previous treatments.
This drug is usually prescribed to young women by a specialist, so he must familiarize the woman with all the subtleties of treatment with the medicine in question. The only restrictive advice to this group of patients may be a recommendation not to use metronidazole suppositories during menstruation. The point is not allergies or other pathological reactions when using a similar dosage form. Vaginal suppositories practically lose their healing power during this period, since the vaginal flora levels the healing effect of the drug.
Metronidazole can be successfully used to treat most diseases in women caused by protozoan parasites. However, the key to success in treating such a pathology will be the patient's scrupulous implementation of all the recommendations of the doctor.
Forms of release and composition
Metronidazole (in Latin - Metronidazolum) has several forms of release:
- Gel outer.
- Topical cream.
- Tablets Metronidazole, film coated. They are flat, have white color. You can buy them in a plastic jar (20 pcs.) Or a blister (10 pcs.).
- Solution for infusions (injections). It is packaged in 0.5 l containers.
- Vaginal gel. Such a drug is in tubes of 30 g.
- Suppositories Metronidazole used in gynecology.
Metronidazole is an antiprotozoal drug with antibacterial effect. The agent is used to treat infections of different localization.
The main active ingredient is metronidazole. The tablets additionally contain potato starch, talc and stearic acid. They contain 250 mg of the main component. The solution contains 5 mg of metranidazole, in vaginal suppositories - 0.125-0.5 g (optional polyethylene oxide), in the gel - 1 g (also propylene glycol, carbomer, sodium hydroxide and water). The cream contains 10 g of the main active ingredient. Among the additional components are: cetyl alcohol, glycerol, synthetic olbroth, stearic acid.
The drug is rapidly absorbed in all tissues of the body. The main active substance is found in the internal organs, bile, amniotic fluid, saliva. Bioavailability is 80%. The maximum concentration of metronidazole in the body is reached after 6-12 hours.
Metronidazole is metabolized in the liver. With its alcoholic lesion, this process is delayed for 10-29 hours. The half-life is 6-12 hours. The medicine is released through the kidneys (60-80%). Metronidazole is able to penetrate the blood-brain barrier and into breast milk.
What is Metronidazole prescribed for?
Indications for use of Metronidazole are as follows:
- infectious pathologies caused by unicellular protozoan pathogens: amebiasis of the intestinal and extraintestinal types, urogenital trichomoniasis,
- abscesses in the liver,
- pathological processes developing in the structures of the nervous system,
- bacterial infections of the support apparatus,
- inflammation or abscess of the lungs,
- endocarditis (infectious lesion of the heart cavities),
- blood poisoning,
- infections of the skin and soft tissues: acne vulgaris, trophic ulcers, wounds that do not heal for a long time, demodicosis,
- chronic alcoholism (for men and women),
- tumor pathologies for the treatment of which radiation therapy is applied,
- gastric and duodenal ulcer, provoked by Helicobacter pylori.
Metronidazole is prescribed to women for inflammation of the reproductive organs: lesions of the vaginal fornix, the inner layer of the uterine wall, and the fallopian tubes. Sometimes it is used to prevent postoperative infection.
The drug Metronidazole is named for the active ingredient in its composition. Once in the patient's body, the substance metronidazole has a detrimental effect on the parasites, impairing the function of respiration and causing cell death. In addition, this drug prevents DNA synthesis in parasitic protozoa, which leads to their early death.
After taking the drug inside, it is well absorbed by the body and penetrates into all the tissues and fluids of the patient. During treatment with metronidazole, a high concentration of anthelmintic substances is created in the patient's saliva, vaginal secretions, or seminal fluid of the patient, which helps to quickly cope with the disease and speed up recovery.
Metronidazole is available in four dosage forms:
- Tablets Metronidazole for oral administration. They have a yellow-green color and a cylindrical shape. Each tablet contains 250 mg of active ingredient. In one package Metronidazole is 10 tablets.
- Cream and gel for external use. Available in aluminum tube. Cream Metronidazole is sold in a volume of 25 g. Each tube of cream contains 250 mg of the active ingredient. The gel is sold in a tube weighing 30 g. Each tube contains 300 mg of metronidazole substance. A special applicator is applied to the packaging of the gel.
- Vaginal candles. They look like small candles, oblong, white or yellow. This form of metronidazole is intended for the treatment of diseases of the female reproductive system. Each vaginal suppository contains 500 mg of active ingredient. In one package there are 7 candles.
- Metronidazole solution. Liquid pale green color, 1 mg of which contains 5 g of the active substance. The solution is available in small bottles of 100 ml. This form of metronidazole is intended for intravenous administration of the drug with a syringe.
For the most effective treatment, you can apply different forms of the drug at the same time.
For example, in the treatment of vaginitis caused by protozoan parasites, you can use Metronidazole tablets and suppositories.
Instructions for use of the drug
Metronidazole effectively helps with tracking parasitic infections:
- Amebiasis intestinal and extraintestinal,
- Cutaneous leishmaniasis
- Vaginitis and urethritis Trichomonas,
Before using the drug, the patient should consult with a parasitologist or infectious diseases specialist who can choose the most effective treatment regimen.
Pills. The correct dosage of metronidazole in the treatment of parasitic invasion in adults is selected depending on the type of microorganisms that hit the patient and the stage of the disease.
- Trichomoniasis. Dosage for adults - 1 tablet (250 mg) twice a day. The entire course of treatment is 10 days. Another treatment regimen involves accelerated care for the patient. To do this, double the dose of the drug and take 2 tablets (500 mg) of Metronidazole in the morning and evening. But it should reduce the duration of the treatment course to 5 days. With the defeat of trichomonads organs of the female reproductive system, patients must also be given intravenous injections with Metronizadol solution. After the end of the course of treatment, a two-week break should be taken, after which the therapy should be repeated for complete recovery of the patient.
- Amebiasis. In asymptomatic amebiasis, the dosage for adults is 2 tablets (500 mg) of metronidazole three times a day. Treatment course - 1 week. In chronic amebiasis in adults and children over 12 years old, take 2 tablets in the morning, afternoon and evening (1.5 g per day). This therapeutic therapy lasts from 5 to 10 days. For the adult patient to recover completely from acute amoebic dysentery, he needs to take 3 tablets three times a day (2.25 g per day) until the symptoms of the disease disappear. Liver abscess. In the treatment of adult patients, the dosage can reach 2.5 g per day - 3 tablets three times a day. With this disease, metronidazole must be combined with antibacterial drugs from the tetracycline group. In this case, the general course of treatment is 5-6 days.
- Ureaplasmosis. The dose of metronidazole for ureaplasmosis for patients older than 12 years is 1 tablet twice a day (500 mg per day). In severe cases, the dosage can be increased to 3 tablets in the morning, in the afternoon and in the evening (750 mg per day).
Ointment and cream. Metronidazole in the form of ointment and cream is most often used to treat diseases of the reproductive system in women. These drugs are especially effective in the fight against vaginitis.
As a rule, patients are recommended to use the drug in a dosage equal to the full applicator, that is, 5 g of Matronidazole. The medicine should be inserted into the vagina in the morning after sleep and in the evening before going to bed. The total duration of the course of treatment is 5 days.
Solution. For the treatment of the most severe stages of parasitic diseases, as well as the patient's rejection by the patient of tableting the form of the drug, Metronidazole solution is used, which is injected into the patient intravenously by injection.
- For adults and children from 12 years and older - a dose of 500 mg of the active ingredient at a time. For the best effect of the drug on the patient's body, the solution must be injected slowly in 5 ml over 6 seconds. There must be at least 8 hours between two injections of metronidazole. In total, within one day the patient is allowed to enter no more than 4 g of the drug.
- For patients suffering from renal or hepatic insufficiency, the maximum dosage of Meronidazole is 1 g per day (1000 mg). For the most effective and safe use of the drug, this dose should be divided into three equal parts and administered to the patient intravenously in the morning, afternoon and evening.
When using intravenous injections of metronidazole in the treatment of a patient, it is strictly forbidden to use other forms of this drug, such as tablets, ointments, creams and suppositories, as this can lead to severe overdose.
Metronidazole for menstruation: you can drink or better to refuse
Substance metronidazole - an assistant in the fight against various infections. It is used in many drugs: the same name Metronidazole, Trichopol and others. Women who are prescribed to take medicine with this active substance often worry if metronidazole can cause menstruation and how it works. Metronidazole for menstruation can be drunk, or is it better to interrupt its use for this period?
What is metronidazole
Before you understand how the drug works during menstruation, you need to figure out why gynecologists prescribe its use.
The substance is available in the form of tablets, gels, injections and suppositories. All types of drugs acting with the use of metronidazole have a powerful effect on microbes and bacteria. At the same time, viral diseases, as well as fungal diseases, are not treated with it. But to be afraid of its impact should be the pathogenic microorganisms of many species that have settled in the body.
Gynecologists prescribe the use of this substance in such cases:
- infections that are transmitted through sexual contact,
- pathology of the fallopian tubes,
- diseases of the uterus (inflammation, endometritis),
- pathology of vaginal microflora,
- parasitic invasions,
- cystitis, urethritis,
- inflammation of the ovaries,
- inflammation in the vagina (vaginitis).
In some cases, metronidazole is used before surgery and for prophylactic purposes after it.
Indications and contraindications for menstruation
Metronidazole can be taken during the critical days in the same way as in their absence. Although this drug has an extensive list of potential side effects.
So, if you drink tablets that contain metronidazole, overdose can cause:
- stomach upset,
- dryness or taste in the mouth of the metal,
- decrease in the level of neutrophils in the blood,
- decrease in the content of leukocytes.
Injections may cause pain or swelling in their place.
If the substance enters the body through candles and gel, the following effects may occur:
- stomach upset,
- intestinal colic,
- high degree of excitability,
- trouble sleeping
- urination disorders
- inflammation of the bladder,
- allergic reactions
- muscle and joint pain.
However, the menstrual cycle does not have the property of being disturbed when using metronidazole. Most antibiotics have no effect on the duration and nature of menstruation. Such a situation would rather be a rare exception.
If there is a delay while taking the medication, it is most likely due to the inflammatory process or infection against which the drug is directed.
The stability of the menstrual cycle and menstruation to some extent shows a woman that other processes in her body are not disturbed. Since all systems are interconnected, naturally, the pathological effect caused by the disease also extends to the reproductive system.
Sometimes the delay in menstruation when using this medication may be due to pregnancy. Is it possible or not to apply trichopolum during menstruation? The answer to this question, is it possible to take Trichopolum or another drug with metronidazole for menstruation, positive.
Fully effective cure of infections and inflammations of the genitourinary system is possible only with the full course of the drug. Therefore, it is impossible to pause the therapy for the time during which the menstrual cycle lasts. Instead of being cured, a woman can only aggravate her condition. Taking pills should always continue throughout the course prescribed by the doctor, without interruption.
There is only one thing about the use of metronidazole during menstruation. If a gel, cream or suppositories are chosen as a therapeutic drug, their use when menstruation does not give the desired effect. Discharge will wash the gel or cream from the vaginal walls, and it will not be able to be absorbed. The same effect will be with candles. Therefore, about the reception of funds during menstruation, you should consult with your doctor.
What can combine metronidazole
Метронидазол можно использовать во многих случаях, исключая эти:
- Комбинация Метронидазола и Амоксициллином для юных девушек до 16 лет нежелательна.
- In the process of curing sexually transmitted and urinary diseases, abstinence in sexual life is recommended. At the same time, both partners should take antibacterial treatment.
- Do not combine with antacid agents containing aluminum hydroxide - efficiency will decrease.
- To harm the body can simultaneous use of the active substance simultaneously with alcohol. Metronidazole oxidizes ethanol, which causes disturbances in the nervous system, nausea, vomiting and pain.
- When taken simultaneously with indirect anticoagulants, metronidazole enhances their action, there is a risk of bleeding.
- Metronidazole in combination with lansoprazole can provoke the appearance of stomatitis, glossitis, dark coloring of the tongue.
If you follow all the recommendations of the doctor, side effects should not occur.
The active substance is the same substance Metronidazole. Once in a sick body, the element inhibits the development of parasites and leads to their death. In addition, the drug also prevents the production of DNA and pathogenic bacteria, accelerating their elimination.
The drug is perfectly absorbed by the body and gets to all the fluids and tissues of the patient or patient. At the same time in the semen, vaginal secretions and saliva formed an increased concentration of special substances that have a positive effect on recovery.
Metronidazole is available in several formats:
Pills. They have a cylindrical shape and greenish-yellow coloring. Packaging of the drug contains 10 tablets.
Experts note that the greatest efficiency can be achieved by combining several forms of a tool at the same time. For example, when fighting vaginitis, it is advisable to use Metronidazole suppositories and pills.
Indications for use
The unique composition of the drug allows it to be used to treat many pathologies. Of the main indications are the following:
- extraintestinal or intestinal amebiasis,
- skin leishmaniasis
- urethritis and vaginitis,
Before using Metronidazole, it is imperative to consult an infectious disease specialist and parasitologist. Only a specialist can choose the most effective therapeutic tactics.
The scheme of using tablets, creams and solution is selected depending on the characteristics of the patient and the type of pathological bacteria. However, it should be remembered that when using the drug in the form of a special injection solution it is forbidden to resort to its other forms, otherwise you may encounter an overdose.
Side effects and contraindications
Metronidazole is a non-toxic agent, so it is very rarely accompanied by side effects. They often occur with prolonged use of the drug. So, by-effects of the means include:
- Allergies: increase in body temperature, rash, asthma, sneezing, runny nose.
- The digestive system: nausea, dry mouth, loss of appetite, cramps and pain in the abdominal cavity.
- Urinary system: cystitis, incontinence.
- CNS: sleep disturbance, depressive states, headaches, hallucinations.
- Other signs: joint pain, thrush, a decrease in the level of white blood cells in the blood.
To prevent "side effects", using Metronidazole, you need to adhere to the correct dosage, which was prescribed by the doctor.
Use of the drug is contraindicated in the presence of such diseases:
- acute liver and kidney failure
- CNS diseases,
In addition, Metronidazole is undesirable to take during lactation and pregnancy.
Use during menstruation
Thinking about whether you can drink Metronidazole during your period, it can be concluded that menstruation does not belong to the group of contraindications to the use of metronidazole. In addition, experts not only do not prohibit, but also recommend using it at this time.
By stopping the course of treatment during the menstrual cycle, there is a risk to aggravate the disease. Therefore, Metronidazole with monthly can drink without interrupting treatment for a day. However, doctors advise to use the tablet form of the drug, because other types will be ineffective. The fact is that the active substances of gels and creams are simply washed away by secretions from the walls of the vaginal cavity and do not have time to fully absorb.
The same applies to vaginal suppositories. Menstruation in this case will prevent the stable absorption of the healing components that are present in the products. Therefore, during the menstrual cycle to use them impractical. One way or another, but before using any drug, it is necessary to consult a doctor who will determine all possible contraindications and an effective therapeutic regimen.
How to take metronidazole
In order to prevent the development of resistance of pathogenic microorganisms to a drug, a person first tests for their sensitivity to the main active substance. The dosage of the drug Metronidazole depends on the form of release and the severity of the disease:
- Giardiasis. Adults are prescribed from 750 to 1000 mg per day. Children from 2 to 15 years old - 250-500 mg. The medicine is used after meals for 2-3 approaches.
- Trichomoniasis. A woman is given 1 tablet (250 mg) in 2 doses.
- Anaerobic infections. Here the dosage is 1.5 g per day. This rate is divided into several techniques.
Treatment of chronic alcoholism is stretched for a long time, while tablets are taken twice a day. Therapy of patients with tumors is coordinated with the regimen prescribed by the oncologist.
Metronidazole - what is it?
Metronidazole is an antibiotic that destroys harmful bacteria in the body. Metronidazole is used to treat bacterial infections of the genital, gastrointestinal and respiratory tract, skin and joints. Metronidazole is not used to treat vaginal fungal infections.
Important information about metronidazole
Take metronidazole in strict accordance with the instructions of the doctor for the recommended period.
In no case do not interrupt the course of treatment at the first sign of improvement or disappearance of the symptoms of the disease: this does not mean that you have gotten rid of the infection.
In addition, non-compliance with the dosage and irregular intake of metronidazole can lead to the formation of antibiotic resistance in bacteria.
Metronidazole is not used to treat common viral infections, such as the common cold or flu. During treatment with metronidazole, alcohol should be avoided, plus 48 hours after the last intake, since acetaldehyde accumulation may occur as a result of a violation of ethanol oxidation. As a result, side effects are possible: increased heart rate, redness and itching of the skin, nausea and vomiting.
What you need to know before taking metronidazole
Metronidazole should not be taken by persons suffering from intolerance to metronidazole or its drugs, as well as pregnant women (for up to 12 weeks) and lactating women. Be sure to tell your doctor if you are expecting a baby or planning a pregnancy.
Also tell your doctor if you are allergic to any medications, as well as the following diseases:
- diseases of the gastrointestinal tract, such as Crohn's disease,
- diseases of the hematopoietic system, such as anemia (lack of red blood cells) or leukemia (lack of white blood cells),
- lack of coordination of movements, organic lesions of the nervous system (including epilepsy),
- severe hepatic and renal failure,
- nervous disorders.
Metronidazole should not be taken in the first trimester of pregnancy. The use of the drug in the II and III trimesters is possible only in cases where the intended benefit to the mother outweighs the potential risk to the fetus.
If you need to use metronidazole during lactation, breastfeeding should be stopped for a while, as the drug penetrates into breast milk and can cause harm to the health of the child.
Dosage and method of use of metronidazole
For oral trichomoniasis, adults are prescribed in a single dose of 250 mg in the morning and evening for 10 days. After completing the course of treatment, several laboratory tests should be carried out (every 3-4 weeks).
In amebiasis, adults are prescribed 250 mg 3 times / day. The course of treatment is 5-10 days, children are given a dose of 35-50 mg / kg / day. The daily dose should be divided into 3 doses. The course of treatment is 10 days.
With giardiasis inside, adults and children over 10 years old are prescribed 500 mg / day, children aged 6-10 years old - 375 mg / day, 2-5 years old - 250 mg / day. The daily dose should be divided into 2 doses. The course of treatment is 5-10 days. After completing the course of treatment, several laboratory tests should be conducted. If necessary, treatment can be repeated after 4-6 weeks.
For the treatment of infectious diseases caused by anaerobic bacteria, adults and children over 12 years old, the drug is administered intravenously every 8 hours in 100 ml of a 0.5% solution (500 mg). Infusion is carried out with a speed of 5 ml / min. The maximum daily dose for intravenous administration is 4 g. The course of infusion therapy is 7-10 days, if necessary = 2-3 weeks. For children under the age of 12, the dose for intravenous administration is set at the rate of 7.5 mg / kg body weight (1.5 ml of a 0.5% solution of metronidazole) every 8 hours. The drug is administered intravenously, slowly. Metronidazole is also prescribed orally in a single dose of 250 to 500 mg.
For the prevention of infections caused by anaerobic bacteria (before abdominal surgery, in obstetric and gynecological practice), the use of an infusion solution of metronidazole should be started 5-10 minutes before surgery. For adults and children over 12 years old, the drug is administered at a dose of 500 mg (100 ml of a 0.5% solution) intravenously in a drip slowly, repeat the infusion after 8 hours. Prophylactically, the drug is used no more than 12 hours after surgery. For children under the age of 12, the dose for intravenous administration is set at the rate of 7.5 mg / kg body weight (1.5 ml of a 0.5% solution of metronidazole).
Metronidazole is also prescribed by mouth. For adults and children over 12 years old, the first single dose is 1 g (4 tab. 250 mg), then 250 mg 3 times daily during or after meals, before the onset of preoperative fasting, children 5 to 12 years old, 125 mg every 8 hours for 2 days.
Store metronidazole at room temperature in a dry dark place. Do not use after the expiration date printed on the package.
Can I skip metronidazole?
If you forget to take metronidazole, correct this mistake as soon as possible. If it is time to take the next dose of the drug, do not double the dose to compensate for the missed medication.
What to do if you exceed the dose of metronidazole?
In case of overdose of metronidazole, consult a doctor immediately. Symptoms of metronidazole overdose: convulsions, peripheral neuropathy, after a single oral administration of 15 g of metronidazole, nausea, vomiting, and incoordination of movements is possible.
Special recommendations for treatment with metronidazole
During treatment with metronidazole, alcohol should be avoided, plus 48 hours after the last intake, since acetaldehyde accumulation may occur as a result of a violation of ethanol oxidation.
Side effects: palpitations, redness and itching of the skin, nausea and vomiting.
Carefully read the information on the packaging of medicines or food to make sure that they do not contain alcohol.
Taking antibiotics may cause diarrhea, which may indicate a new infection. If diarrhea occurs, stop taking metronidazole and consult a doctor. Remedies for diarrhea can be taken only on the recommendation of a doctor.
Is it possible and how to take metronidazole during menstruation?
Many diseases of the female genital tract caused by protozoan parasites require continuous therapy for a certain time. The course of medication may coincide with the onset of menstruation. If metronidazole is selected for treatment, can it be prescribed to patients during or during menstruation?
The considered drug is one of the main medical ways to combat Giardia or amoebae in the human body. Specialists get good results in treating trichomoniasis with this medicine in patients. Like any other aggressive drug, metronidazole has its own specifics, which often depends on the medicinal form used in medical practice.
The composition of the tool
The main active ingredient of the drug is metronidazole, the amount of which varies depending on the type of medication:
- The solution contains 0.5 grams per 100 ml.
- Tablet form is available in a volume of 0.25 and 0.5 grams.
- Candles also contain half a gram of active substance.
May also include starch, solid fat, sodium chloride, silica, calcium stearate and other substances.
What diseases are treated with the drug?
Doctors prescribe "Metronidazole" in the presence of the following pathologies in the patient's body:
- Protozoosis - diseases caused by the simplest organisms. Among them are: amebic disintheria, abscess, trichomoniasis, balantidiasis, vaginitis and others.
- Bacteroid infections: meningitis, endocarditis, endometritis, empyema, and pneumonia.
- Diseases caused by Helicobacter pylori: gastritis or ulcer.
- Alcohol addiction.
- Oncological diseases, which are treated with radiation. In this case, the drug plays the role of a radiosensitizing agent.
Metronidazole is also prescribed for the prevention of postoperative complications.
"Metronidazole": instructions for use in gynecology
The tool is widely used for the treatment of gynecological diseases. If there are any pathologies of the reproductive system in the treatment of this drug is recommended to refrain from sexual activity. In identifying diseases that are sexually transmitted, both partners need to undergo a course of treatment. During menstruation, therapy should be continued, as well as pass control tests before and after menstruation. Metronidazole is prescribed for the following gynecological pathologies:
- Bacterial vaginosis. Occurs after taking oral contraceptives and a large number of antibacterial drugs, previous diseases of the genitourinary system, as well as due to non-compliance by the woman with the rules of intimate hygiene.
- Abscesses Congestion of pus can be observed in the cavity of the ovaries and fallopian tubes. Pathology inherent tendency to expansion. An abscess can cause infertility, so if you have the first symptoms (painful sensations in the lower abdomen and fever), you should consult a specialist. Purulent inflammation is treated combined with the help of surgical methods and antibacterial therapy.
- Cystitis. Inflammatory processes in the bladder, which are characteristic of this disease, are usually accompanied by severe discomfort: painful urination, frequent urging to the toilet, burning sensation and hyperthermia. At the initial stage, the disease can be cured without the help of antibiotics, however, with the intensification of symptoms, antibacterial treatment becomes necessary.
- Trichomoniasis. The disease is dangerous not only for the female, but also for the male body. The complexity of its diagnosis lies in the fact that the pathology may be asymptomatic, but over time the disease leads to infertility and difficulties in carrying the fetus. Trichomoniasis is transmitted during sexual intercourse. Its causative agent is trichomoniasis, which can be eliminated with the help of Metronidazole.
In the treatment of gynecological diseases, it is recommended to carry out complex therapy: combine antibiotics with local drugs, as well as take medications that strengthen the immune system of the woman.
"Metronidazole" instructions for use: tablets
Therapy with this antibacterial drug should be carried out no more than ten, but not less than five days. The drug in the form of tablets should be taken after a meal or drink a glass of milk. The drug is not recommended to chew or chop. "Metronidazole" pill instruction:
- Trichomoniasis should be treated with 250 or 400 mg twice a day for ten and seven days, respectively. Repeated administration of the drug, if after a course of antibiotic tests show the presence of Trichomonas, can be carried out only a month after taking the last pill. Also, the doctor has the right to increase the dosage of the drug.
- Giardia will eliminate the intake of 500 mg of the drug twice a day for a week. Такая же дозировка и время приема рекомендованы при амебиазе, стоматите, колите, балантидиозе, алкогольной зависимости, анаэробных инфекциях и абсцессах.
- To avoid complications after surgery, an expert can prescribe from 750 to 1500 mg three times a day for three days before surgery and a single dose of 500 mg after.
Reception means allowed children up to a year, but the dosage must be determined individually by the pediatrician depending on the characteristics of the child’s body and the course of the disease.
Other dosage forms:
- "Metronidazole" candles: instructions for use. Treatment of gynecological diseases involves the use of candles in conjunction with other drugs of systemic action. The gynecologist at the reception should suggest how to use "Metronidazole" candles: the instruction usually suggests inserting one candle into the vagina before going to bed. The duration of treatment is from a week to ten days. Therapy can be repeated after 1-1.5 months.
- "Metronidazole" gel: instructions for use involves applying a thin layer to the affected area in the morning and evening after washing. Treatment can last up to four months, and the first visible effect appears after three weeks. The ointment is prescribed for the treatment of acne, pressure sores, cracks, eczema and other dermatological diseases.
The ointment is not able to cope with some dermatological diseases, so you should not use it yourself. Also, with prolonged treatment may be addictive. To avoid this, it is necessary to take breaks between courses.
“When I just bought Metronidazole ointment, the instructions for use promised me a result for three weeks. It upset me a little, because I was determined not to have a quick cure for acne, but the dermatologist advised to be patient. One and a half months after the complex treatment, my skin has changed dramatically. Now, the rash doesn’t bother me much. ”
Alexandra, 19 years old
“After giving birth, she often suffered from candidiasis and vaginitis. The gynecologist prescribed Metronidazole tablets and suppositories for a more effective result. Ten days later, the diseases retreated, and I felt relief after a few days. The only minus of the drug - had to interrupt breastfeeding. Now I take drugs to restore the vaginal microflora. "
Sofia, 26 years old
“A few months ago, I treated this drug with bacterial vaginitis as instructed by the gynecologist. The insert has been written about side effects, and I experienced some of them on myself. During the week I felt tired and weak, my head ached and I was very sick. The drug helped get rid of the disease, but the second time I would not take it. ”
Anna, 30 years old
Women often ask whether it is possible to continue the treatment of gynecological diseases during menstruation. This also concerns trikhopol, many ask whether it is possible to take Trikhopol tablets inside during menstruation and continue topical treatment with vaginal tablets.
Under which gynecological diseases are prescribed Trichopolum and how do menstruation affect them
Trichopolum is a drug that suppresses the vital activity of the simplest. For gynecological diseases caused by protozoa, is primarily trichomoniasis. The causative agent of this infection Trichomonas vaginalis is very sensitive to trichopols. But in some cases, trichomoniasis is long and asymptomatic (latent). To identify and treat this disease is difficult. Often, in order to do this, you need to shake the body, which will cause an aggravation of the infection.
Any infection is easier to treat in a state of aggravation. Various types of provocations are often used for “shaking up” - the introduction of drugs that can cause an exacerbation of the disease. Menstruation is a natural provocation - it contributes to the exacerbation of any infectious-inflammatory gynecological process. Therefore, gynecologists use menstruation as a natural provocation.
Another common reason for prescribing Trichopolum is bacterial vaginosis. This is not a disease, but vaginal dysbacteriosis. Vaginal disbacteriosis - how to deal with it ?. It can develop for various reasons, most often this occurs against the background of the frequent uncontrolled use of antibiotics, which leads to the suppression of the vital activity of the normal natural microflora of the vagina. The natural microflora of the vagina in a healthy woman creates an environment uncomfortable for reproduction of conditionally pathogenic microflora. When the natural microflora is suppressed, opportunistic begins to grow - this is dysbacteriosis.
Most often grows the volume of colonies Gardnerell - bacteria that are sensitive to trichopol. If bacterial vaginosis is not treated, then creating favorable conditions for reproduction of conditionally pathogenic microflora (decreased immunity, the common cold) will cause an infectious-inflammatory process. Manifestation of bacterial vaginosis in the form of abundant secretions with an unpleasant "fish" smell.
Finally, infectious-inflammatory processes of the internal female genital organs, caused by anaerobic (developing without air access) bacteria, are possible. As a rule, these are severe inflammatory processes that are difficult to treat with antibiotics, to which addiction of infectious agents often develops. And here also Trichopol Trichopol can come to the rescue - what does it cure ?, addiction to which pathogens develops very slowly. Natural provocation in the form of menstruation in the treatment of these diseases will also benefit.
Is it possible or not to apply trichopolum during menstruation?
Treatment of gynecological diseases Trichopolum is carried out according to special schemes. In some cases, Trichopolum is appointed independently, in others, its purpose is combined with the appointment of antibiotics. In any case, Trichopolum is taken for some specific time and the course of treatment (as well as the course of treatment with any other drug) should not be interrupted.
Intake of trichopol inside and its introduction into a vein during menstruation should not be interrupted. But the local use of Trichopol Trichopol - the indications for use are quite wide during menstruation loses its meaning, because the medicine, instead of lingering in the vagina until it is completely absorbed, is washed out and removed along with the menstrual blood.
Therefore, topical trichopolum in the form of vaginal tablets during menstruation is not recommended. At the same time, nothing terrible will happen even if a woman continues to use vaginal pills during her period.
Trichopolum has few contraindications for use. These are the first twelve weeks of pregnancy, breastfeeding. Breastfeeding is a personal choice by the breast and individual intolerance to the components of the drug.
Of the side effects can be noted headache, dizziness, insomnia, bad mood, convulsive readiness, tinnitus and even hearing loss, fainting. Nausea, vomiting, diarrhea or constipation, poor appetite, disgusting metallic taste in the mouth, taste disturbances, abdominal cramps are also possible. There may be changes in the blood, it is a transient leukopenia (decrease in the number of blood leukocytes) and thrombocytopenia (decrease in the number of blood platelets). As with the use of any other medication, allergic reactions are possible. When intravenous trichopolum may develop thrombophlebitis.
How to dilute the solution
The specified drug is diluted with a 0.9% sodium chloride solution or 5% glucose. If intravenous antibiotics are prescribed simultaneously with the patient, they should be administered separately.
Side Effects and Overdose with Metronidazole
The drug Metronidazole can cause such side effects:
- nausea and vomiting, dry mouth,
- may develop a disulfiram-like reaction,
- urinary incontinence,
- violation of the chair,
- redness of the skin, allergic reactions, rash,
- headache, sleep disturbance, neuropathy, hallucinations.
After consuming Metronidazole, a patient may develop a depressive state.
In case of overdose, symptoms of intoxication, vomiting and nausea, peripheral neuropathy are observed. There is no specific antidote. After an overdose, you need to flush the stomach. Further symptomatic therapy is carried out.
With other drugs
This tool is used in a complex treatment regimen. Perhaps this interaction:
- Use with Disulfiram increases the risk of adverse reactions from the nervous system.
- Phenobarbital and its derivatives reduce the concentration of antiprotozoal agent in the blood plasma.
- Medicines containing lithium together with the indicated drug provoke the development of intoxication.
With simultaneous use of metronidazole with anticoagulants and sulfonamides increases the antimicrobial effect.
During pregnancy and lactation
The main component of the drug is able to penetrate the placental barrier, into the amniotic fluid, so it is not prescribed to women in early pregnancy.
In 2-3 trimester Metronidazole is prescribed strictly for medical reasons, if the danger to the life of the mother exceeds the risk of injury to the fetus.
Breastfeeding at the time of therapy will have to stop.
In childhood, the tool is used for the treatment of parasitic invasions: giardiasis. In this case, you can not use it in combination with Amoxicillin. Children are prescribed a suspension for oral administration or a tablet form of the drug. For infants up to one year, the maximum dosage is 125 mg per day.
Is it possible to use during menstruation
It is not necessary to refuse therapy during menstrual bleeding.
With long-term treatment should monitor blood counts. In the presence of symptoms of intoxication, you must immediately stop taking the drug and consult a doctor. At the time of treatment of diseases of the reproductive system is required to refrain from sexual activity. When this is the simultaneous treatment of both partners.
When using products for topical use, you need to ensure that they do not fall into the eyes. For the application of the presented drug is characterized by dark staining of urine. In this case, the dosage is not necessary to adjust.
Since the drug affects the functionality of the nervous system, for the period of treatment should refuse to drive a car or perform work with moving mechanisms that require increased attention.
Storage conditions and shelf life
The shelf life of candles and tablets is 2 years. Keep it out of the reach of children. Storage temperature is + 23 ... + 25 ° С.
Regardless of the dosage form, Metronidazole can adversely affect the functionality of the body. In this case, you can apply an analogue. The feasibility of its use should be coordinated with the doctor.
What can replace the drug with its intolerance
If it is necessary to replace the drug, adults can offer the following options: Trichopol, Flagyl, Klion, Metrogil, Batsimeks, Deflamon, Metrovagin, Metronidal, Rozex.
Irina, 28 years old, Astrakhan
When visiting the doctor was diagnosed with trichomoniasis. Specialist appointed Metronidazole in combination with antibiotics. After a few days, the discomfort disappeared, but dizziness and nausea appeared. I decided to continue the therapy, but the side effects became stronger. From this drug had to be abandoned.
Oksana, 17 years old, Komsomolsk-on-Amur
The doctor prescribed this remedy for the treatment of acne. The ointment worked immediately: the discomfort was gone. After 2 days, the first positive results were noticed: acne became less, skin color returned to normal. No side effects noticed, I recommend for women.
Alexandra, 35 years old, Krasnoyarsk
After prolonged agony with cystitis, the doctor prescribed Metronidazole. After 3 days it became easier, seizures are repeated less frequently. Pain and other symptoms go away half an hour after ingestion.